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What is Dexedrine (Dextroamphetamine)?

Dexedrine, or Dextroamphetamine, is a powerful central nervous system (CNS) stimulant and amphetamine enantiomer. It is primarily prescribed for treating attention deficit hyperactivity disorder (ADHD) and narcolepsy. It is also known for its use as a cognitive enhancer and, occasionally, as an athletic performance booster.

Key Uses of Dexedrine

  • ADHD Treatment: Helps improve focus and reduce hyperactive behavior.
  • Narcolepsy: Manages excessive daytime sleepiness and sudden sleep attacks.
  • Performance Enhancement: Used recreationally to boost cognitive and athletic performance.
  • Military Use: Historically used by military personnel to stay alert during extended missions.

How Dexedrine Works

  • Mechanism: Dextroamphetamine stimulates the CNS by increasing the levels of neurotransmitters such as serotonin, norepinephrine, and dopamine.
  • Enantiomers: The amphetamine molecule has two enantiomers – levoamphetamine and dextroamphetamine. Dextroamphetamine is the more potent enantiomer affecting the CNS.

Dosage and Forms

  • Available Forms: Sold as brand-name and generic drugs in various dosages.
  • Prodrug Form: Sometimes prescribed as lisdexamfetamine dimesylate, which converts to dextroamphetamine after absorption.

Potential Side Effects

  • Common Side Effects: Insomnia, dry mouth, loss of appetite, increased heart rate.
  • Serious Side Effects: High potential for addiction, possible nerve damage with long-term use, especially at high doses.
  • Long-Term Use: Can lead to tolerance and dependence.

Important Considerations

  • Brain Development: In ADHD patients, pharmaceutical amphetamines can improve brain development and nerve growth.
  • Off-Label Uses: Occasionally prescribed for conditions such as depression and obesity.
  • Safety: Long-term use should be monitored by a healthcare provider to avoid adverse effects.

History and Availability

  • Discovery and Usage: Widely used for various medical and non-medical purposes.
  • Military and Civilian Use: Effective for enhancing performance and managing sleep disorders.

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