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What is Demerol (Pethidine)?

Demerol, also known as Pethidine or Meperidine, is a synthetic opioid pain medication from the phenylpiperidine class. It is commonly used for the treatment of moderate to severe pain.

Key Information About Demerol

  • Class: Synthetic opioid.
  • Discovered by: Otto Eisleb in 1938.
  • Analgesic Properties Recognized by: Otto Schaumann.
  • Forms: Available in tablets, syrup, and injectable forms (intramuscular, subcutaneous, intravenous).


  • Pain Management: Effective for moderate to severe pain relief.
  • Common Use: Previously favored by physicians for acute and chronic severe pain.

How Demerol Works

  • Mechanism: Acts on the central nervous system to relieve pain.
  • Onset: Rapid action for quick relief.
  • Duration: Provides effective pain relief for several hours.

Potential Side Effects

  • Common Side Effects: Nausea, vomiting, constipation, dizziness, drowsiness.
  • Serious Side Effects: Breathing difficulties, addiction risk, and potential for serotonin syndrome.
  • Toxicity: Norpethidine metabolite can be neurotoxic, especially with long-term use.

Important Considerations

  • Addiction Risk: Similar to other opioids, there is a significant risk of dependence.
  • Myths Debunked: Initially thought to be safer than morphine, but carries similar risks.
  • Drug Interactions: Can interact with serotonergic drugs, increasing the risk of serotonin syndrome.
  • Use in Labor: Commonly used in labor and delivery, but alternatives are preferred in some countries due to potential risks.

History and Availability

  • Patented: 1937.
  • Approved for Medical Use: 1943.
  • Global Usage: Still widely used in the UK and New Zealand, but less favored in the U.S.

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