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What is Clonazepam (Klonopin)?

Clonazepam, known by the brand name Klonopin, is a benzodiazepine medication used to treat and prevent seizures, panic disorder, and akathisia (a movement disorder). It is taken orally and begins working within an hour, with effects lasting between 6 to 12 hours.

Key Uses:

  • Seizure Control: Effective in preventing and treating various types of seizures.
  • Panic Disorder: Helps manage panic attacks and associated anxiety.
  • Movement Disorders: Alleviates symptoms of akathisia.

Dosage and Administration

  • Form: Tablets taken by mouth.
  • Dosage: Typically prescribed in 2mg doses, but follow your doctor’s instructions for precise usage.

Potential Side Effects

  • Common Side Effects: Sleepiness, poor coordination, agitation.
  • Long-Term Use: May lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly.
  • Pregnancy Risks: Can cause harm to the baby if used during pregnancy.

Important Considerations

  • Tolerance and Dependence: One-third of users may develop dependence after more than four weeks of use.
  • Mental Health Risks: Increased risk of suicide in individuals with pre-existing depression.
  • Mechanism: Binds to GABAA receptors, enhancing the effects of GABA, the chief inhibitory neurotransmitter.

History and Availability

  • Patented: 1960 by Roche.
  • Marketed: Available in the United States since 1975.
  • Generic Options: Widely available as a generic medication.
  • Cost: Affordable pricing, with wholesale costs in the developing world between $0.01 and $0.07 per pill, and around $0.40 per pill in the U.S.
  • Prescription Rates: Ranked as the 42nd most prescribed medication in the U.S. in 2016, with over 18 million prescriptions.

Usage in Epilepsy and Acute Seizures

  • Acute Treatment: Effective for the short-term management of seizures, but not recommended for long-term use due to tolerance.
  • Childhood Epilepsies: Useful for certain rare childhood epilepsies at low plasma levels.
  • Non-Convulsive Status Epilepticus: Effective in the acute control, but often requires additional medications like phenytoin for sustained control.

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