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What is Clonazepam (Klonopin)?

Clonazepam, known by the brand name Klonopin, is a benzodiazepine medication used to treat and prevent seizures, panic disorder, and akathisia (a movement disorder). It is taken orally and begins working within an hour, with effects lasting between 6 to 12 hours.

Key Uses:

• Seizure Control: Effective in preventing and treating various types of seizures.
• Panic Disorder: Helps manage panic attacks and associated anxiety.
• Movement Disorders: Alleviates symptoms of akathisia.

Dosage and Administration

• Form: Tablets taken by mouth.
• Dosage: Typically prescribed in 2mg doses, but follow your doctor’s instructions for precise usage.

Potential Side Effects

• Common Side Effects: Sleepiness, poor coordination, agitation.
• Long-Term Use: May lead to tolerance, dependence, and withdrawal symptoms if stopped abruptly.
• Pregnancy Risks: Can cause harm to the baby if used during pregnancy.

Important Considerations

• Tolerance and Dependence: One-third of users may develop dependence after more than four weeks of use.
• Mental Health Risks: Increased risk of suicide in individuals with pre-existing depression.
• Mechanism: Binds to GABAA receptors, enhancing the effects of GABA, the chief inhibitory neurotransmitter.

History and Availability

• Patented: 1960 by Roche.
• Marketed: Available in the United States since 1975.
• Generic Options: Widely available as a generic medication.
• Cost: Affordable pricing, with wholesale costs in the developing world between $0.01 and $0.07 per pill, and around $0.40 per pill in the U.S.
• Prescription Rates: Ranked as the 42nd most prescribed medication in the U.S. in 2016, with over 18 million prescriptions.

Usage in Epilepsy and Acute Seizures

• Acute Treatment: Effective for the short-term management of seizures, but not recommended for long-term use due to tolerance.
• Childhood Epilepsies: Useful for certain rare childhood epilepsies at low plasma levels.
• Non-Convulsive Status Epilepticus: Effective in the acute control, but often requires additional medications like phenytoin for sustained control.

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