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What is Dexedrine ER (Dextroamphetamine)?

Dexedrine ER is an extended-release form of Dextroamphetamine, a powerful central nervous system (CNS) stimulant. It is commonly prescribed for treating attention deficit hyperactivity disorder (ADHD) and narcolepsy. Additionally, it is used as a cognitive enhancer and has historical military applications as a performance booster during fatigue-inducing missions.

Key Uses of Dexedrine ER

  • ADHD Treatment: Improves focus and reduces hyperactivity.
  • Narcolepsy: Manages excessive daytime sleepiness and sudden sleep attacks.
  • Performance Enhancement: Used recreationally to boost cognitive function and athletic performance.
  • Military Use: Used historically to maintain alertness during extended operations.

How Dexedrine ER Works

  • Mechanism of Action: Dextroamphetamine stimulates the CNS by increasing levels of neurotransmitters like serotonin, norepinephrine, and dopamine.
  • Enantiomers: The amphetamine molecule has two forms – levoamphetamine and dextroamphetamine. Dextroamphetamine, the more potent form, has a stronger effect on the CNS.

Dosage and Forms

  • Available Forms: Offered as brand-name and generic drugs in various dosages.
  • Prodrug Form: Sometimes prescribed as lisdexamfetamine dimesylate, which converts to dextroamphetamine after absorption.

Potential Side Effects

  • Common Side Effects: Insomnia, dry mouth, loss of appetite, increased heart rate.
  • Serious Side Effects: Risk of addiction, potential nerve damage with long-term use.
  • Long-Term Use: Monitoring by a healthcare provider is recommended to avoid adverse effects.

Important Considerations

  • Brain Development: In ADHD patients, pharmaceutical amphetamines can improve brain development and nerve growth.
  • Off-Label Uses: Occasionally prescribed for conditions such as depression and obesity.
  • Safety: Long-term use requires careful supervision to mitigate potential risks.

History and Availability

  • Discovery and Usage: Widely used for various medical and non-medical purposes.
  • Military and Civilian Use: Effective for enhancing performance and managing sleep disorders.

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