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What is Dexedrine ER (Dextroamphetamine)?

Dexedrine ER is an extended-release form of Dextroamphetamine, a powerful central nervous system (CNS) stimulant. It is commonly prescribed for treating attention deficit hyperactivity disorder (ADHD) and narcolepsy. Additionally, it is used as a cognitive enhancer and has historical military applications as a performance booster during fatigue-inducing missions.

Key Uses of Dexedrine ER

• ADHD Treatment: Improves focus and reduces hyperactivity.
• Narcolepsy: Manages excessive daytime sleepiness and sudden sleep attacks.
• Performance Enhancement: Used recreationally to boost cognitive function and athletic performance.
• Military Use: Used historically to maintain alertness during extended operations.

How Dexedrine ER Works

• Mechanism of Action: Dextroamphetamine stimulates the CNS by increasing levels of neurotransmitters like serotonin, norepinephrine, and dopamine.
• Enantiomers: The amphetamine molecule has two forms – levoamphetamine and dextroamphetamine. Dextroamphetamine, the more potent form, has a stronger effect on the CNS.

Dosage and Forms

• Available Forms: Offered as brand-name and generic drugs in various dosages.
• Prodrug Form: Sometimes prescribed as lisdexamfetamine dimesylate, which converts to dextroamphetamine after absorption.

Potential Side Effects

• Common Side Effects: Insomnia, dry mouth, loss of appetite, increased heart rate.
• Serious Side Effects: Risk of addiction, potential nerve damage with long-term use.
• Long-Term Use: Monitoring by a healthcare provider is recommended to avoid adverse effects.

Important Considerations

• Brain Development: In ADHD patients, pharmaceutical amphetamines can improve brain development and nerve growth.
• Off-Label Uses: Occasionally prescribed for conditions such as depression and obesity.
• Safety: Long-term use requires careful supervision to mitigate potential risks.

History and Availability

• Discovery and Usage: Widely used for various medical and non-medical purposes.
• Military and Civilian Use: Effective for enhancing performance and managing sleep disorders.

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