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What is Demerol (Meperidine)?

Demerol, also known as Meperidine, is an opioid pain medication used to treat moderate to severe pain. Similar to morphine, Demerol belongs to the class of drugs known as narcotics. It works by affecting the brain to change how your body feels and responds to pain.

Key Benefits of Demerol:

• Effective Pain Relief: Demerol is prescribed for acute pain management, providing quick and effective relief.
• Oral Solutions: Demerol oral solution is a pleasant-tasting, non-alcoholic, banana-flavored solution that makes it easier to consume.

Pharmacodynamics:

Demerol functions by directly acting on the brain’s respiratory centers, causing respiratory depression and miosis (pupil constriction), even in low light conditions.

Dosage and Administration:

• Tablets and Oral Solution: Demerol 50mg tablets and oral solution are typically prescribed for acute pain management.
• Bioavailability: The oral bioavailability of Demerol is around 50%, with its active metabolite, normeperidine, having an elimination half-life of 20.6 hours.
• Metabolism: Demerol is primarily metabolized by CYP3A4 and CYP2B6 enzymes and is excreted by the kidneys. The elimination half-life ranges from 3 to 8 hours in healthy individuals, and 1.3 to 2 times longer in postoperative or cirrhotic patients.

Side Effects:

Common side effects of Demerol include:

• Nausea and vomiting
• Constipation
• Sweating
• Lightheadedness and dizziness
• Drowsiness
• Pain or redness at the injection site
• Mood changes (euphoria, dysphoria)
• Weakness
• Headache
• Agitation
• Tremor
• Involuntary muscle movements
• Severe convulsions
• Transient hallucinations and disorientation
• Visual disturbances

Demerol may also increase serotonin levels and, in rare cases, lead to serotonin syndrome, a serious condition requiring immediate medical attention.

Drug Interactions:

• Phenytoin: May elevate hepatic metabolism of Demerol.
• Ritonavir and Acyclovir: May raise plasma concentration of normeperidine, the active metabolite.

Precautions:

• Opioid Addiction Risk: Patients using Demerol are exposed to the risk of opioid addiction, abuse, and misuse.
• Serotonin Syndrome: Monitor for symptoms of serotonin syndrome, especially when taken with other serotonergic drugs.

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Disclaimer: Demerol is a prescription medication and should only be used under the supervision of a healthcare professional. Misuse can lead to dependence and other serious health risks.

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