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What is 25I-NBOMe?

25I-NBOMe, also known as 2C-I-NBOMe and N-Bomb, belongs to the phenethylamine chemical class, renowned for its visually dominant and stimulating psychedelic effects upon administration.

Key Features of 25I-NBOMe

• Chemical Derivative: Derived from the psychedelic 2C-I, synthesized initially in 2003 by Ralf Heim at the Free University of Berlin and extensively researched thereafter.
• Administration: Not orally active; it is sublingually administered for optimal absorption over 15-25 minutes.
• Research and Development: Investigated as a potential ligand for mapping 5-HT2A receptors in the brain using PET scans.

Safety and Usage

Due to its potent effects and sensitive dose-response, caution is advised when handling 25I-NBOMe. It is associated with risks such as unpredictable effects, making adherence to harm reduction practices essential.

• Limited Research: Minimal data exists on its pharmacological properties, metabolism, and toxicity in humans.
• Historical Context: Emerged as a designer drug in 2010 without prior human use, associated with incidents of hospitalizations and fatalities.

Chemical Structure and Effects

25I-NBOMe is a substituted phenethylamine featuring methoxy groups CH3O- at carbons R2 and R5, alongside an iodine atom at carbon R4. Structurally distinct from 2C-I, it substitutes the amine (NH2) with a 2-methoxybenzyl (BOMe) group, characteristic of the NBOMe family.

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